반응 #158552

반응 방정식

(3-acetoxyphenyl]-5-fluoro-2,4-pyrimidinediamine

N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

acetyl chloride

pyridine

→

N2,N4-Bis(3-acetyloxyphenyl)-5-fluoro-2,4-pyrimidinediamine

용매

CH2Cl2

반응 조건

실험 절차

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-acetoxyaniline were reacted to yield N2,N4-bis[(3-acetoxyphenyl]-5-fluoro-2,4-pyrimidinediamine. Alternatively, N2,N4-bis[(3-acetoxyphenyl]-5-fluoro-2,4-pyrimidinediamine can be prepared by acetylation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine with acetyl chloride in the presence of pyridine in CH2Cl2. 1H NMR (CDCl3): δ 8.00 (bs, 1H), 7.51-7.25 (m, 8H), 2.32 (s, 3H), 2.28 (s, 3H); LCMS: ret. time: 22.14 min; purity: 100%; MS (m/e): 397 (MH+).

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