반응 #1584569

반응 방정식

methanol

water

methyl 1-(2,3-dimethyl-2H-indazol-5-yl)-2-oxo-1,2-dihydropyridine-4-carboxylate

diisobutylaluminum hydride

→

title compound

수율 54.0%

1-(2,3-dimethyl-2H-indazol-5-yl)-4-(hydroxymethyl)pyridin-2(1H)-one

수율 54.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   여과the mixture was filtered through celite
2. 2
   농축concentrated under reduced pressure
3. 3
   기타The obtained residue was purified by silica gel column chromatography (dichloromethane/methanol)

실험 절차

To a solution of methyl 1-(2,3-dimethyl-2H-indazol-5-yl)-2-oxo-1,2-dihydropyridine-4-carboxylate (450 mg) in dichloromethane (40 ml) was added diisobutylaluminum hydride (1 M toluene solution, 7.5 ml) at −78° C., and the mixture was stirred at the same temperature for 2 hr. To the reaction mixture were added methanol and water at the same temperature, and the mixture was filtered through celite, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (dichloromethane/methanol) to give the title compound (220 mg).

출처