반응 #1584552

반응 방정식

ammonia

5-bromo-2,3-dimethyl-2H-indazole

4-(benzyloxy)pyridin-2(1H)-one

potassium carbonate

N,N′-dimethylethylenediamine

→

title compound

수율 65.3%

4-(benzyloxy)-1-(2,3-dimethyl-2H-indazol-5-yl)pyridin-2(1H)-one

수율 65.3%

용매

DMSO

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to room temperature
2. 2
   기타the obtained precipitates
3. 3
   여과were collected by filtration
4. 4
   세척The obtained solid was washed with water and diisopropyl ether
5. 5
   기타dried under reduced pressure

실험 절차

A suspension of 5-bromo-2,3-dimethyl-2H-indazole (1.85 g), 4-(benzyloxy)pyridin-2(1H)-one (1.65 g), potassium carbonate (3.41 g), copper(I) iodide (1.57 g) and N,N′-dimethylethylenediamine (0.73 g) in DMSO (30 ml) was stirred at 150° C. for 3 hr. The reaction mixture was cooled to room temperature, and added to 28% aqueous ammonia, and the obtained precipitates were collected by filtration. The obtained solid was washed with water and diisopropyl ether, and dried under reduced pressure to give the title compound (1.85 g).

출처