반응 #1584538

반응 방정식

sodium hydroxide

5-bromo-3-methyl-1H-indazole

trimethyloxonium tetrafluoroborate

→

title compound

수율 80.5%

5-bromo-2,3-dimethyl-2H-indazole

수율 80.5%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타To the obtained reaction mixture
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   세척The organic layer was washed with saturated brine
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축concentrated under reduced pressure

실험 절차

To a solution of 5-bromo-3-methyl-1H-indazole (4.25 g) in ethyl acetate (100 ml) was added trimethyloxonium tetrafluoroborate (4.47 g) at room temperature, and the mixture was stirred at the same temperature for 5 hr. To the obtained reaction mixture was added 1 M aqueous sodium hydroxide solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (3.65 g).

출처