반응 #158418

반응 방정식

HCl

NaOH

ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate

NaOH

→

3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid

수율 100.0%

용매

MeOH

반응 조건

후처리

1. 1
   workup.STIRRINGto stir for 3 hrs
2. 2
   추출the product was extracted with EtOAc
3. 3
   세척The extract was washed with water and brine
4. 4
   건조dried over Na2SO4
5. 5
   기타evaporated

실험 절차

To a solution of ethyl 3-(1-(3,4-difluorophenyl)cyclohexyl)propanoate (540 mg, 1.822 mmol) in MeOH (15 mL) was added 1N NaOH (3.64 mL, 3.64 mmol), and the mixture was stirred at room temperature for 20 hrs. Since the reaction was not complete on TLC, an additional 1.82 mL of 1N NaOH was added, and it was continued to stir for 3 hrs. TLC showed that the reaction was complete. Next, the reaction mixture was acidified with the addition of 6 mL of 1N HCl, and the product was extracted with EtOAc. The extract was washed with water and brine, dried over Na2SO4, and evaporated to give 3-(1-(3,4-difluorophenyl)cyclohexyl) propanoic acid (489 mg, 1.822 mmol, 100% yield) as a white solid.

출처