반응 #1583806

반응 방정식

methyl 2,4-dichloro-3-hydroxybenzoate

potassium carbonate

nonafluoro-n-butanesulfonyl chloride

→

clean product

수율 16.2%

methyl 2,4-dichloro-3-(nonafluoro-n-butylsulfonyloxy)benzoate

수율 16.2%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.ADDITIONFor workup, the contents were poured onto ice-water
2. 2
   추출the mixture was extracted with ethyl acetate
3. 3
   기타The organic phase was dried
4. 4
   기타the filtrate was freed of the solvent on a rotary evaporator
5. 5
   기타The residue was purified by chromatography, which

실험 절차

9.5 g (43.0 mmol) of methyl 2,4-dichloro-3-hydroxybenzoate in 240 ml of acetonitrile were admixed with 8.6 g (62.2 mmol) of potassium carbonate and then with 9.5 ml (52.8 mmol) of nonafluoro-n-butanesulfonyl chloride. The reaction mixture was stirred at room temperature (RT) for 16 h. For workup, the contents were poured onto ice-water and the mixture was extracted with ethyl acetate. The organic phase was dried and the filtrate was freed of the solvent on a rotary evaporator. The residue was purified by chromatography, which gave 3.5 g of clean product.

출처