반응 #158314

반응 방정식

3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

sodium methoxide

→

title compound

3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

용매

DMF

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration
2. 2
   세척washed with water

실험 절차

To a mixture of 3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile (0.51 g) in DMF (10 mL) was added sodium methoxide (5M methanol solution, 1.51 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was added to ice water, and the precipitated solid was collected by filtration, and washed with water to give the title compound (0.34 g).

출처