반응 #158293

반응 방정식

Lawesson's reagent

ethyl 3-(3,4-difluorophenyl)-2-oxopiperidine-3-carboxylate

→

title compound

수율 116.1%

ethyl 3-(3,4-difluorophenyl)-2-thioxopiperidine-3-carboxylate

수율 116.1%

용매

toluene

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   기타the solvent was evaporated under reduced pressure
3. 3
   기타The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

실험 절차

Under an argon atmosphere, Lawesson's reagent (1.00 g) was added to a suspension of ethyl 3-(3,4-difluorophenyl)-2-oxopiperidine-3-carboxylate (1.00 g) in toluene (20 mL) at room temperature. The reaction mixture was stirred at 110° C. for 4 hr, and allowed to cool to room temperature, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (859 mg).

출처