반응 #1581847

반응 방정식

6-chloro-1-trimethylsilylhex-1-yne

sodium iodide

→

6-iodo-1-trimethylsilylhex-1-yne

수율 96.2%

용매

butanone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux
3. 3
   기타After this time the solvent was removed in vacuo
4. 4
   기타the residue partitioned between diethyl ether and water
5. 5
   기타The organic phase was separated
6. 6
   세척washed with water and brine
7. 7
   건조before drying over anhydrous magnesium sulphate
8. 8
   기타The solvent was removed under reduced pressure

실험 절차

A mixture of 6-chloro-1-trimethylsilylhex-1-yne (14.0 g.) and sodium iodide (30 g) in butanone (100 ml) was heated at reflux, with stirring, for 10 hours. After this time the solvent was removed in vacuo and the residue partitioned between diethyl ether and water. The organic phase was separated, washed with water and brine before drying over anhydrous magnesium sulphate. The solvent was removed under reduced pressure to leave 6-iodo-1-trimethylsilylhex-1-yne as a yellow oil (20.0 g).

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