반응 #158172

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[2-(tert-butyldimethylsilanyloxy)propyl]-(2,4-dichloro-6-nitrobenzyl)amine

1-(4,6-dichloro-2H-indazol-2-yl) propan-2-one

2-[2-(tert-butyldimethylsilanyloxy)propyl]-4,6-dichloro-2H-indazole

→

2-Amino-3-(4,6-dichloro-2H-indazol-2-yl)-2-methylpropionitrile

수율 54.0%

1-(4,6-Dichloro-2H-indazol-2-yl)propan-2-one

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후처리

1. 1
   기타was prepared

실험 절차

2-Amino-3-(4,6-dichloro-2H-indazol-2-yl)-2-methylpropionitrile (88 mg, 54%) was prepared using a procedure similar to that described in Example 1, part b, except starting from 1-(4,6-dichloro-2H-indazol-2-yl) propan-2-one (146 mg). 1-(4,6-Dichloro-2H-indazol-2-yl)propan-2-one was prepared using a procedure similar to that described in Example 105 part c and d except starting from 2-[2-(tert-butyldimethylsilanyloxy)propyl]-4,6-dichloro-2H-indazole that was prepared using a procedure similar to that described in Example 132 part a except starting from [2-(tert-butyldimethylsilanyloxy)propyl]-(2,4-dichloro-6-nitrobenzyl)amine described in Example 116.

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