반응 #158088

반응 방정식

5-methoxycarbonylmethyl-furan-2-carboxylic acid methyl ester

NaOH

→

5-carboxymethyl-furan-2-carboxylic acid

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent is removed under reduced pressure and 2.78 mL of 1N HCl
2. 2
   workup.ADDITIONis added to the residue

실험 절차

To a solution of 5-methoxycarbonylmethyl-furan-2-carboxylic acid methyl ester (250 mg, 1.26 mmol) in methanol (5 mL) is added 1N NaOH (2.78 mL, 2.78 mmol) and the mixture is stirred at room temperature for 18 hours. The solvent is removed under reduced pressure and 2.78 mL of 1N HCl is added to the residue. The resulting solution is lyophilized to give 5-carboxymethyl-furan-2-carboxylic acid.

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