반응 #1579760

반응 방정식

3-chloro-4-hydroxy-5-methoxy-benzaldehyde

methyl 2-bromophenylacetate

K2CO3

→

title compound

수율 64.0%

methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate

수율 64.0%

용매

acetone

반응 조건

후처리

1. 1
   온도was refluxed for 14 h
2. 2
   온도The mixture was cooled
3. 3
   여과filtered
4. 4
   기타evaporated in vacuo
5. 5
   기타the residue was purified by flash chromatography on a silica gel column

실험 절차

A mixture of 0.50 g (2.65 mmol) of 3-chloro-4-hydroxy-5-methoxy-benzaldehyde, 0.668 g (2.92 mmol) of methyl 2-bromophenylacetate and K2CO3 (0.73 g, 5.3 mmol) in acetone (8 mL) was refluxed for 14 h. The mixture was cooled, filtered and evaporated in vacuo, and the residue was purified by flash chromatography on a silica gel column using 5% ethylacetate in hexane to afford 0.570 g (64%) of the title compound.

출처