반응 #157964

반응 방정식

hydrochloric acid dioxane

tert-butyl 4-cyano-4-(hydroxymethyl)piperidine-1-carboxylate

→

4-(hydroxymethyl)piperidine-4-carbonitrile hydrochloride

용매

dioxane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure

실험 절차

4 M hydrochloric acid/dioxane solution (15 ml) was added to a solution of tert-butyl 4-cyano-4-(hydroxymethyl)piperidine-1-carboxylate (886 mg) in dioxane (5 ml), and stirring was performed for one hour at room temperature. The reaction mixture was concentrated under reduced pressure, and 4-(hydroxymethyl)piperidine-4-carbonitrile hydrochloride (663 mg) was obtained.

출처