반응 #157865

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(5R)-5-[2-(5-cyclopropyl-6-methoxypyridin-2-yl)-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-2-one

hexane

→

title compound

3-Cyclopropyl-6-{1-(2,3-dihydro-1-benzofuran-5-yl)-2-[(2R)-5-oxopyrrolidin-2-yl]ethyl}pyridin-2(1H)-one

용매

ethanol

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후처리

1. 1
   기타was obtained as a yellow amorphous (78 mg)
2. 2
   기타the same reaction as in Examples 4-207 and 4-208(3) except

실험 절차

An (R,S) mixture of the title compound was obtained as a yellow amorphous (78 mg) by performing substantially the same reaction as in Examples 4-207 and 4-208(3) except for using (5R)-5-[2-(5-cyclopropyl-6-methoxypyridin-2-yl)-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-2-one. This was preparatively isolated by a chiral HPLC column (CHIRALPAK IB, hexane:ethanol=30:70 v/v, 40° C., 10 mL/min, 210 nm) to give one diastereomer (A) of the title compound as a colorless amorphous (50 mg) and the other diastereomer (B) of the title compound as a colorless amorphous (45 mg).

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