반응 #1577745

ord-36a20897034c441f9bf4fb79b7aa05c4

반응 방정식

Brc1cccs1
Brc1cccs1
→
CC1(C)OB(c2ccc(Br)s2)OC1(C)C
CC1(C)OB(c2ccc(Br)s2
수율 96.0%

반응물

Brc1cccs1
Brc1cccs1
CAS: 1003-09-4

시약

C1=CCCC=CCC1.C1=CCCC=CCC1.C[OH2+].C[OH2+].[Ir].[Ir]
C1=CCCC=CCC1.C1=CCCC=CCC1.C[OH
CAS: 12148-71-9
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C
CC1(C)OB(B2OC(C)(C)C(C)(C)O2)O
CAS: 73183-34-3
c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1
c1ccc(N2B(B3Nc4ccccc4N3c3ccccn
CAS: 1799485-16-7

용매

COC1CCCC1
COC1CCCC1
CAS: 5614-37-9

반응 조건

온도
100°CELSIUS

실험 절차

The general procedure A was followed using 2-bromothiophene (48.4 uL, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5t was obtained as orange oil (138.7 mg, 96 %) after purification by silica gel flash chromatography (EtOAc/PE=1:40 v/v);

출처

DOI: 10.1021/jacs.5b05252Borylation dataset from Roche