반응 #157748

반응 방정식

Water

Potassium hydroxide

1-bromo-2-methylpropane

2-(4-bromophenyl)ethylalcohol

→

title compound

수율 70.0%

1-Bromo-4-[2-(2-methylpropoxy)ethyl]benzene

수율 70.0%

용매

dimethyl sulfoxide

반응 조건

후처리

1. 1
   추출followed by extraction with dichloromethane
2. 2
   여과The organic layer was filtered through diatomaceous earth
3. 3
   기타the filtrate was evaporated under reduced pressure
4. 4
   기타The residue was purified by silica gel column chromatography (hexane only)

실험 절차

Potassium hydroxide (1.32 g) and 1-bromo-2-methylpropane (1.04 mL) were added to a solution of 2-(4-bromophenyl)ethylalcohol (140 μL) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, followed by extraction with dichloromethane. The organic layer was filtered through diatomaceous earth and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane only) to give the title compound as a colorless oil (180 mg, 70%).

출처