반응 #1575

반응 방정식

4'-chloro-2'-fluoro-5'-nitroacetanilide

hydrogen

→

title product

5'-Amino-4'-chloro-2'-fluoroacetanilide

용매

ethanol tetrahydrofuran

반응 조건

후처리

1. 1
   여과The reaction mixture is then filtered
2. 2
   농축concentrated in vacuo

실험 절차

A mixture of 4'-chloro-2'-fluoro-5'-nitroacetanilide (35.2 g, 151 mmol), and 5% platinum on carbon (7.0 g, 20 wt/wt %) in an ethanol/tetrahydrofuran (2:1) solution is hydrogenated until 28 psi of hydrogen is taken up. The reaction mixture is then filtered, and concentrated in vacuo to give the title product as a tan solid which is identified by 1H NMR spectral analysis.

출처