반응 #1573972

반응 방정식

Ethyl N-piperazinecarboxylate

5-bromo-1-pentanol

potassium carbonate

→

oil

수율 52.0%

ethyl 4-(5-hydroxypentyl)piperazinecarboxylate

수율 52.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타separated by column chromatography (eluent: dichloromethane/methanol/triethylamine system, v/v/v 100:1:0.5)

실험 절차

Ethyl N-piperazinecarboxylate (25.50 g, 161.39 mmol), 5-bromo-1-pentanol (26.96 g, 161.39 mmol), potassium carbonate (55.68 g, 403.48 mmol) and anhydrous acetonitrile (200 mL) were placed in a 500 mL round-bottomed flask and heated under reflux with stirring overnight; the reaction system was cooled down to room temperature, filtered, concentrated and separated by column chromatography (eluent: dichloromethane/methanol/triethylamine system, v/v/v 100:1:0.5), to obtain a pale yellow oil 20.48 g, yield 52.0% (which was directly used in the next step reaction).

출처