반응 #1573909

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2.001c

1-[3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester

5-methylnicotinoyl chloride

2.001a

4-Chloro-N-(3-[1,3]dioxolan-2-yl-phenyl)-benzamide

rac-(2S*,4S*)-methyl 2-methylpiperidine-4-carboxylate

→

title compound

rac-(2S*,4S*)-2-Methyl-1-{3-[(5-methyl-pyridine-3-carbonyl)-amino]-benzyl}-piperidine-4-carboxylic acid

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실험 절차

The title compound is prepared according to the reaction sequence 2.001a-2.001d described above using 5-methylnicotinoyl chloride instead of 4-chlorobenzoyl chloride as in 2.001a and rac-(2S*,4S*)-methyl 2-methylpiperidine-4-carboxylate instead of ethyl isonipecotate as in 2.001c: LC-MS A: tR=0.67 min; [M+H]+=422.08.

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