반응 #1573906

반응 방정식

2.001c

1-[3-(4-Chloro-benzoylamino)-benzyl]-piperidine-4-carboxylic acid ethyl ester

2-(2-chloro-4-fluorophenyl)acetyl chloride

2.001a

4-Chloro-N-(3-[1,3]dioxolan-2-yl-phenyl)-benzamide

methyl pyrrolidine-3-carboxylate

→

title compound

rac-1-{3-[2-(2-Chloro-4-fluoro-phenyl)-acetylamino]-benzyl}-pyrrolidine-3-carboxylic acid

반응 조건

실험 절차

The title compound is prepared according to the reaction sequence 2.001a-2.001d described above using 2-(2-chloro-4-fluorophenyl)acetyl chloride instead of 4-chlorobenzoyl chloride as in 2.001a and methyl pyrrolidine-3-carboxylate instead of ethyl isonipecotate as in 2.001c: LC-MS A: tR=0.63 min; [M+H]+=391.01.

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