반응 #1573860

반응 방정식

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid

1-chloroethyl cyclooctyl carbonate

→

title compound

수율 18.2%

(1S,2S,3S,5R,6S)-2-Amino-6-((1-(((cyclooctyloxy)carbonyl)oxy)ethoxy)carbonyl)-3-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

수율 18.2%

반응 조건

실험 절차

(1S,2S,3S,5R,6S)-3′-((Allyloxy)carbonyl)-3-fluoro-5′-oxospiro[bicyclo[3.1.0]hexan-2,4′-oxazolidine]-6-carboxylic acid (A-1-2, 380 mg) and 1-chloroethyl cyclooctyl carbonate (A-11-1, 745 mg) were treated in the same manner as in Example A-1 (3) and (4) to give the title compound (A-11, 93 mg) as a colorless solid.

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