반응 #157287

반응 방정식

methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate

methylhydrazine

→

product

수율 80.3%

2-(5-hydroxy-1-methyl-1H-pyrazol-3-ylmethyl)-isoindol-1,3-dione

수율 80.3%

용매

ethanol

반응 조건

후처리

1. 1
   온도The reaction mixture is cooled
2. 2
   여과suction filtered
3. 3
   세척washed with ethanol

실험 절차

10.0 g methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate are dissolved at 60° C. in 200 ml of ethanol and 1.94 g methylhydrazine are added. The reaction mixture is cooled and stirred further at ambient temperature. After 5 hours the precipitated substance is suction filtered and washed with ethanol. 7.91 g of the product are obtained as a powder.

출처