반응 #157271

반응 방정식

2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine

(R)-1-amino-1-(4-fluoro-phenyl)-2-methyl-propan-2-ol

diisopropylethylamine

→

product

수율 28.5%

(R)-1-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-1-(4-fluoro-phenyl)-2-methyl-propan-2-ol

수율 28.5%

용매

dioxane

반응 조건

후처리

1. 1
   기타evaporated to dryness
2. 2
   workup.ADDITIONThe residue is mixed with water
3. 3
   기타The precipitate formed
4. 4
   여과filtered
5. 5
   기타purified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40)

실험 절차

533 mg 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine, 850 mg (R)-1-amino-1-(4-fluoro-phenyl)-2-methyl-propan-2-ol and 1.3 ml diisopropylethylamine are suspended in 9.8 ml dioxane. The reaction mixture is stirred for 2 hours in the microwave at 80° C. and then evaporated to dryness. The residue is mixed with water. The precipitate formed is suction filtered and purified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40). 260 mg of the product are obtained as a solid.

출처