반응 #157268

반응 방정식

water

2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine

D-valinamide hydrochloride

diisopropylethylamine

→

product

수율 74.0%

(R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide

수율 74.0%

용매

dioxane

반응 조건

후처리

1. 1
   기타The precipitate formed
2. 2
   여과filtered
3. 3
   기타dried

실험 절차

800 mg 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine and 800 mg D-valinamide hydrochloride are placed in 8 ml dioxane, then 2.7 ml diisopropylethylamine are added. The reaction mixture is heated to 120° C. in the microwave for 2 hours. The residue is mixed with water. The precipitate formed is suction filtered and dried. 820 mg of the product are obtained as a powder Analytical HPLC (method R): RT=2.64 min.

출처