반응 #157265

반응 방정식

2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine

diisopropylethylamine

3-morpholin-4-ylmethyl-phenylamine

→

product

수율 70.6%

(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-yl)-(3-morpholin-4-ylmethyl-phenyl)-amine

수율 70.6%

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도after cooling
2. 2
   기타evaporated down
3. 3
   추출The residue is extracted with dichloromethane and water
4. 4
   기타the organic phase is dried
5. 5
   기타evaporated to dryness
6. 6
   기타The residue is crystallised with petroleum ether/ethyl acetate

실험 절차

1.25 g 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine are placed in 5 ml dimethylformamide, first 1.05 ml diisopropylethylamine, then 0.960 g 3-morpholin-4-ylmethyl-phenylamine (J. Med. Chem. 1990, 33, 327) are added. The reaction mixture is sf 20 hours at 60° C., then after cooling evaporated down. The residue is extracted with dichloromethane and water, the organic phase is dried and evaporated to dryness. The residue is crystallised with petroleum ether/ethyl acetate. 1.28 g of the product are obtained as a powder.

출처