반응 #1571695

반응 방정식

2-[4-methyl-3-(trifluoromethoxy)phenoxy]-5-nitropyridine

Intermediate 30

2-[4-methyl-3-(trifluoromethoxy)phenoxy]-5-nitropyridine

→

title compound

수율 88.4%

6-[4-methyl-3-(trifluoromethoxy)phenoxy]pyridin-3-amine

수율 88.4%

용매

THF

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   기타to remove the catalyst
3. 3
   workup.ADDITIONdiluted with ethyl acetate (10 mL)
4. 4
   세척washed with an aqueous 13% solution of NaCl (10 mL)
5. 5
   건조The organic layer, dried over Na2SO4
6. 6
   기타was evaporated

실험 절차

A suspension of 2-[4-methyl-3-(trifluoromethoxy)phenoxy]-5-nitropyridine (Intermediate 30, 594 mg, 1.89 mmol) and Pd/C 5% w/w (40 mg) in THF (3 mL) was hydrogenated under 5 bar of H2, at 35° C. for 18 hrs. The mixture was filtered to remove the catalyst, diluted with ethyl acetate (10 mL) and washed with an aqueous 13% solution of NaCl (10 mL). The organic layer, dried over Na2SO4, was evaporated to give the title compound (475 mg) as brown oil.

출처