반응 #157050

반응 방정식

1-(3-nitropyridin-4-yl)piperazine

N-Boc-beta-alanine

HOAT

EDC

→

tert-butyl 3-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-3-oxopropylcarbamate

수율 93.0%

용매

EtOAc

DCM

반응 조건

후처리

1. 1
   세척was washed with H2O, Na2CO3(sat), NaCl(sat.)
2. 2
   건조was dried over MgSO4
3. 3
   여과was filtered
4. 4
   기타the volatiles were removed in vacuo

실험 절차

A solution containing 1.0 eq each of 1-(3-nitropyridin-4-yl)piperazine, N-Boc-beta-alanine, HOAT and EDC in DCM, at a concentration of 0.1 M, was stirred for 16 hours. The solution was diluted with EtOAc and was washed with H2O, Na2CO3(sat), NaCl(sat.), was dried over MgSO4, was filtered and the volatiles were removed in vacuo yielding tert-butyl 3-(4-(3-nitropyridin-4-yl)piperazin-1-yl)-3-oxopropylcarbamate (93%). LCMS (m/z): 379.9 (MH+); LC Rt=1.92 min.

출처