반응 #156901
ord-9ef1577c58434c5b954f71f3b031cea3
반응 방정식
용매
반응 조건
온도
90°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The solid was filtered
- 2세척washed with water
- 3기타dried in vacuum
실험 절차
Tert-butyl 4-(4-cyano-2,5-difluorophenyl)piperazine-1-carboxylate (20 mg, 0.062 mmol) was dissolved in ethanol (1 mL) and treated with water (0.2 mL) and 50% NaOH (0.2 mL, 2.500 mmol). The reaction mixture was stirred at 90° C. for 1 h, diluted with water (2 mL) and acidified with 1N HCl to pH<4. The solid was filtered, washed with water and dried in vacuum to afford 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2,5-difluorobenzoic acid (21.0 mg, 0.061 mmol, 99% yield) as a white solid. ESI-MS: m/z 343 (M+H)+.