반응 #1568699

반응 방정식

DCM

NCS

DCM

ethyl cis-beta-cyanoacrylate

Pivaldehyde

DMF

→

3-tert-Butyl-4-cyano-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester

용매

H2NOH

반응 조건

후처리

1. 1
   workup.STIRRINGThe resulting mixture was stirred at room temperature for 1 h
2. 2
   기타The resulting solution was placed in a dropping funnel
3. 3
   workup.ADDITIONAfter completion of addition
4. 4
   workup.STIRRINGthe resulting mixture was stirred for 8 h at room temperature
5. 5
   농축concentrated under reduced pressure
6. 6
   workup.DISSOLUTIONThe resulting residue was dissolved in DCM (50 mL)
7. 7
   세척washed with H2O (3×30 mL) and brine (30 mL)
8. 8
   건조dried over anhydrous MgSO4
9. 9
   여과filtered
10. 10
    기타The solvent was removed under reduced pressure
11. 11
    기타The resulting residue was chromatographed on a 40-g SiO2 pre-packed column
12. 12
    세척eluting with 0:1-3:7 EtOAc/hexanes

실험 절차

Pivaldehyde (1.63 mL, 15.0 mmol) was dissolved in anhydrous DMF (15 mL) and H2NOH.xH2O (0.860 mL of a 55% aqueous solution, 15.4 mmol) was added via syringe. The resulting mixture was stirred at room temperature for 1 h and NCS (2.06 g, 15.4 mmol) was added as a solid. The resulting mixture was stirred at room temperature for 1 h and DCM (50 mL) was added. The resulting solution was placed in a dropping funnel and added dropwise over 4 h to a stirred DCM (40 mL) solution of ethyl cis-beta-cyanoacrylate (1.98 mL, 16.5 mmol) and TEA (4.18 mL, 30.0 mmol). After completion of addition, the resulting mixture was stirred for 8 h at room temperature and then concentrated under reduced pressure. The resulting residue was dissolved in DCM (50 mL), washed with H2O (3×30 mL) and brine (30 mL), and dried over anhydrous MgSO4 and filtered. The solvent was removed under reduced pressure. The resulting residue was chromatographed on a 40-g SiO2 pre-packed column eluting with 0:1-3:7 EtOAc/hexanes to yield a mixture (˜1:1.6 as measured by 1H-NMR) of 3-tert-Butyl-4-cyano-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester contaminated with ethyl cis-beta-cyanoacrylate. 1H-NMR (400 MHz, CDCl3) δ: 5.22 (d, J=5.1 Hz, 1H), 4.55 (d, J=5.1 Hz, 1H), 4.25-4.32 (m, 2H), 1.35 (s, 9H), 1.31-1.36 (t, J=7.1 Hz, 3H).

출처