반응 #156804

반응 방정식

Methyl 6-chloro-5-nitronicotinate

(S)-methyl piperidine-2-carboxylate

→

title compound

수율 98.0%

(S)-methyl 6-(2-(methoxycarbonyl)piperidin-1-yl)-5-nitronicotinate

수율 98.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction was stirred 1 h at 90° C.
2. 2
   기타The mixture was purified by SiO2 (330 g, 20-30% EA in Hexanes)

실험 절차

Methyl 6-chloro-5-nitronicotinate (2.333 g, 10.77 mmol) was added to (S)-methyl piperidine-2-carboxylate (2.93 g, 20.46 mmol) neat while stirring. The reaction was stirred 1 h at 90° C., cooled to room temperature and taken up in ethyl acetate (10 mL). The mixture was purified by SiO2 (330 g, 20-30% EA in Hexanes) to yield 3.4 g (98%) of the title compound as a yellow oil. [M+H] calc'd for C14H17N3O6, 324; found, 324.

출처