반응 #156752

반응 방정식

(1R,3S)-3-aminocyclopentanecarboxylic acid

methanol

thionyl chloride

→

title compound

(1R,3S)-Methyl 3-aminocyclopentanecarboxylate hydrochloride

반응 조건

후처리

1. 1
   온도to warm to room temperature
2. 2
   workup.STIRRINGstirred overnight
3. 3
   기타The resulting clear solution was evaporated
4. 4
   기타azeotroped with methanol (2×5 mL)
5. 5
   기타air-dried

실험 절차

A suspension of (1R,3S)-3-aminocyclopentanecarboxylic acid (500 mg, 3.8 mmol) in methanol (10 mL) was stirred at 0° C. and thionyl chloride (1.40 mL, 19.3 mmol) was added dropwise. The mixture was allowed to warm to room temperature and stirred overnight. The resulting clear solution was evaporated, azeotroped with methanol (2×5 mL), air-dried and the title compound obtained as a white powder (680 mg).

출처