반응 #1563934

반응 방정식

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

수율 79.8%

2-(2,5-difluorophenyl)pyrrolidine

수율 79.8%

용매

MeOH H2O

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   추출extracted with DCM
3. 3
   건조dried over anhydrous sodium sulphate
4. 4
   농축concentrated under reduced pressure

실험 절차

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

출처