반응 #1563932

반응 방정식

tert-Butyl 2-oxopyrrolidine-1-carboxylate

Isopropyl magnesium chloride

2-bromo-1,4-difluorobenzene

→

title compound

수율 83.3%

tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

수율 83.3%

용매

THF

THF

THF

반응 조건

후처리

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued at 10° C. for 2 h
3. 3
   기타Reaction mixture
4. 4
   기타was quenched with saturated NH4Cl solution
5. 5
   추출extracted with EtOAc
6. 6
   건조dried over anhydrous sodium sulphate
7. 7
   농축concentrated under reduced pressure

실험 절차

2.0 M Isopropyl magnesium chloride solution in THF (163 mL, 324.3 mmol) was added to a solution of 2-bromo-1,4-difluorobenzene (62.5 g, 324.3 mmol) in THF (350 mL) at −40° C. and stirring was continued at 5° C. for 1 h. tert-Butyl 2-oxopyrrolidine-1-carboxylate (Step-1) (73 g, 392 mmol) in THF (150 mL) was added dropwise to above reaction mixture at −40° C. and stirring was continued at 10° C. for 2 h. Reaction mixture was quenched with saturated NH4Cl solution, extracted with EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 76 g of the title compound.

출처