반응 #1563931

반응 방정식

HCl

(R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine

→

title compound

(R)-2-(2,5-difluorophenyl)pyrrolidine Hydrochloride

용매

Dioxane

반응 조건

후처리

1. 1
   농축After which the reaction mixture was concentrated under reduced pressure
2. 2
   기타to afford the crude product
3. 3
   기타The crude product was purified
4. 4
   세척by washing with diethyl ether

실험 절차

4M HCl solution (in Dioxane) (75 mL) was added to stirred solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (15 g, 52.19 mmol) in Dioxane (25 mL) and stirring was continued at 20-35° C. for 4 h. After which the reaction mixture was concentrated under reduced pressure to afford the crude product. The crude product was purified by washing with diethyl ether to afford 7.5 g of the title compound as a white solid.

출처