반응 #1563923

반응 방정식

1-(2,2-dimethoxyethoxy)-4-fluorobenzene

trifluoroacetic acid

→

title compound

2-(4-fluorophenoxy)acetaldehyde

용매

chloroform

반응 조건

후처리

1. 1
   온도heat to 65° C.
2. 2
   workup.STIRRINGstir for 4 h
3. 3
   농축Concentrate the mixture under reduced pressure

실험 절차

Dissolve 1-(2,2-dimethoxyethoxy)-4-fluorobenzene (1.00 g, 4.99 mmol) in chloroform (5.0 mL) and treat the mixture with trifluoroacetic acid (0.755 mL, 9.99 mmol). Stir the mixture at room temperature for two days, then heat to 65° C. and stir for 4 h. Concentrate the mixture under reduced pressure to furnish the title compound as a colorless oil in ca. 70% purity, as indicated by 1H NMR analysis (550 mg, 71% uncorrected yield). 1H NMR (400 MHz, CDCl3): δ 9.85 (t, J=0.5 Hz, 1H), 7.00 (dd, J=8.9, 8.5 Hz, 2H), 6.85 (dd, J=9.5, 4.3 Hz, 2H), 4.55 (br s, 2H).

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