반응 #1563902

반응 방정식

(6-Iodobenzo[d][1,3]dioxol-5-yl)methanol

PCC

→

6-iodobenzo[d][1,3]dioxole-5-carbaldehyde

수율 77.0%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   기타After reaction
2. 2
   기타the crude product was purified by column chromatography on silica gel (petroleum ether)

실험 절차

(6-Iodobenzo[d][1,3]dioxol-5-yl)methanol (2.7 g, 9.7 mmol) in dry CH2Cl2 was added dropwise to PCC (3.1 g, 14.6 mmol) in dry CH2Cl2 at 0° C. under N2 atmosphere. The mixture was stirred at room temperature for 20 h. After reaction, the crude product was purified by column chromatography on silica gel (petroleum ether) to obtain 6-iodobenzo[d][1,3]dioxole-5-carbaldehyde (2 g, 77%) as white solid. LCMS: 277[M+1]+; 1H NMR (DMSO-d6) δ 6.20 (s, 2H), 7.28 (s, 1H), 7.61 (s, 1H), 9.79 (s, 1H).

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