반응 #1563891

반응 방정식

bis(2-bromoethyl)amine

Compound 25

2-amino-N-(2-methoxyphenyl)-6-(4-nitrophenylthi-o)benzamide

NaOH

→

solid

수율 82.0%

N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)-6-(piperazinyl)benzamide

수율 82.0%

용매

DMF

반응 조건

후처리

1. 1
   기타to get crude product
2. 2
   여과The crude solid was filtered
3. 3
   세척washed several times with water
4. 4
   기타purified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether)

실험 절차

Compound 25 (1.0 equiv.) was dissolved in DMF (40 mL) at room temperature. To this mixture bis(2-bromoethyl)amine (1.0 equiv.) was added, following the addition of NaOH (2.0 equiv.). After being stirred for 2 Hours at room temperature, the reaction mixture was poured into ice-cold water (200 mL) to get crude product. The crude solid was filtered and washed several times with water and purified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether) to provide a yellow solid (380.9 mg, 82% yield).

출처