반응 #1563862

반응 방정식

trimethylsilane

phenyl azide

1,1,4,7,7-pentamethyldiethlene triamine

TBAF

THF

→

4-(furan-2-yl)-1-phenyl-1H-1,2,3-triazole

수율 62.2%

반응 조건

후처리

1. 1
   기타it was quenched with saturated ammonium chloride solution
2. 2
   추출was extracted with ethyl acetate
3. 3
   세척The combined organic layers were washed with water
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   기타evaporated
6. 6
   기타The crude material was purified by column chromatography (100-200 mesh silica gel)

실험 절차

To a solution of furan-2-ylethynyl)trimethylsilane (100 mg, 0.6097 mmol), phenyl azide (0.5 M solution, 2.42 ml, 1.2195 mmol), and CuI (116.11 mg, 0.6097 mmol) in THF (2 ml) was added 1,1,4,7,7-pentamethyldiethlene triamine (0.254 ml, 1.2195 mmol) and 1M TBAF.3H2O (1.20 ml, 1.2195 mmol). After stirring the reaction mixture for 20 hours at room temperature, it was quenched with saturated ammonium chloride solution and was extracted with ethyl acetate. The combined organic layers were washed with water, dried over anhydrous sodium sulfate and evaporated. The crude material was purified by column chromatography (100-200 mesh silica gel) using 5% ethyl acetate in hexane as eluent to yield 4-(furan-2-yl)-1-phenyl-1H-1,2,3-triazole (80 mg, 0.378 mmol, yield 62.18%) with an HPLC purity of 98.82%. LC-MS [M+H] 212 (C12H9N3O+H expected 212.07), mp 118-120° C. The 1H-NMR spectra was in accordance with the chemical structure.

출처