반응 #155844

반응 방정식

trisamine

carbonate

2-methyl propanoic acid

oxalyl chloride

2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-amine

→

N-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)isobutyramide

용매

dioxane

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGthis was stirred for a further 4 hours at ambient temperature
2. 2
   여과the sample filtered

실험 절차

To a solution of 2-methyl propanoic acid (62.06 mg, 65.46 μL, 0.7044 mmol) in dioxane (1 mL) with DMF was added oxalyl chloride (87.9 mg, 60.43 μL, 0.6927 mmol) at ambient temperature. The resulting solution was stirred for 30 minutes at this temperature. To this solution was added 2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-amine (50 mg, 0.2347 mmol) and this was stirred for a further 4 hours at ambient temperature. The reaction mixture was then heated to 50° C. for 1 hour. After this time trisamine resin and carbonate resin were added and the sample filtered. This crude solution was taken onto the next step as is.

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