반응 #155436

반응 방정식

2-oxazolidinone

triphosgene

5-methylsalicylaldehyde

pyridine

triethylamine

→

2-formyl-4-methylphenyl 2-oxooxazolidine-3-carboxylate

수율 145.4%

용매

THF

CH2Cl2

MTBE

water

반응 조건

후처리

1. 1
   기타To a 500 mL dry round bottom flask
2. 2
   workup.STIRRINGThe resulting mixture was stirred at room temperature overnight
3. 3
   여과The reaction mixture was filtered
4. 4
   농축the filtrate was concentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in 20 mL of CH2Cl2
6. 6
   workup.STIRRINGAfter stirring at room temperature overnight
7. 7
   여과The mixture was filtered
8. 8
   세척the solid was washed with cold water (20 mL×2)
9. 9
   기타After drying

실험 절차

To a 500 mL dry round bottom flask were added 2-oxazolidinone (9.13 g, 104.9 mmol), triphosgene (10.9 g, 36.7 mmol) and anhydrous THF (100 mL). The mixture was stirred in an ice-water bath, then triethylamine (15.8 mL, 115.4 mmol) was added slowly. The resulting mixture was stirred at room temperature overnight. The reaction mixture was filtered and the filtrate was concentrated. The residue was dissolved in 20 mL of CH2Cl2, and this solution was added slowly to a stirring mixture of 5-methylsalicylaldehyde (10.0 g, 73.4 mmol) and pyridine (8.5 mL, 104.9 mmol) in 30 mL of anhydrous CH2Cl2 at 0° C. After stirring at room temperature overnight, water (50 mL) and MTBE (100 mL) were added to the reaction mixture. The mixture was filtered and the solid was washed with cold water (20 mL×2), followed by MTBE (20 mL×2). After drying, 2-formyl-4-methylphenyl 2-oxooxazolidine-3-carboxylate (13.3 g) was obtained as a white solid. Yield: 73%. 1H NMR (Acetone-d6, 300 MHz): δ=10.25 (s, 1H), 7.78 (s, 1H), 7.62 (d, J=8.1 Hz, 1H), 7.35 (d, J=8.4 Hz, 1H), 4.58 (t, J=7.8 Hz, 2H), 4.32 (t, J=7.5 Hz, 2H), 2.47 (s, 3H).

출처