반응 #155397

반응 방정식

HCl

2-chloro-4-(methylsulfonyl)benzoyl chloride

5-amino-1-(2-methoxyethyl)tetrazole

water

→

2-chloro-4-(methylsulfonyl)-N-(1-(2-methoxyethyl)tetrazol-5-yl)-benzamide

용매

EA

pyridine

반응 조건

후처리

1. 1
   기타The organic phase is separated off
2. 2
   세척washed with 2N HCl and brine
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated
5. 5
   기타purified by RP—HPLC (acetonitrile/water)

실험 절차

176 mg (0.75 mmol) of 2-chloro-4-(methylsulfonyl)benzoyl chloride, 145 mg (1.0 mmol) of 5-amino-1-(2-methoxyethyl)tetrazole in 2 ml of pyridine are stirred at 60° C. for 12 h. 0.1 ml of water is then added, the mixture is stirred at 60° C. for 30 min and EA and 2N HCl are added. The organic phase is separated off and washed with 2N HCl and brine, dried over Na2SO4, concentrated and purified by RP—HPLC (acetonitrile/water). Yield 66 mg (23%).

출처