반응 #155373

반응 방정식

sodium hydroxide

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester

→

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid

용매

ethanol

water

반응 조건

후처리

1. 1
   workup.DISTILLATIONca. 350 mL ethanol were distilled off
2. 2
   workup.ADDITIONca. 100 mL water was added
3. 3
   workup.ADDITIONThen diethylether (50 mL) was added
4. 4
   workup.STIRRINGthe mixture stirred over night
5. 5
   기타The product was isolated by filtration
6. 6
   기타used without further purification

실험 절차

To a solution of sodium hydroxide (50.0 mmol) in 500 mL ethanol and 50 mL water was added 3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (41.4 mmol). The mixture was stirred at room temperature for three hours, then ca. 350 mL ethanol were distilled off, ca. 100 mL water was added and the pH was adjusted to 6. Then diethylether (50 mL) was added and the mixture stirred over night. The product was isolated by filtration and used without further purification.

출처