반응 #155369

반응 방정식

1c

3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester

→

crude product

수율 58.0%

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid methyl ester

수율 58.0%

용매

acetic acid

반응 조건

후처리

1. 1
   온도to reflux for one hour
2. 2
   기타The solution was then evaporated to dryness
3. 3
   기타the remaining solid triturated with water

실험 절차

A solution of the product of 1c (22.6 mmol) in 100 mL concentrated acetic acid was heated to reflux for one hour. The solution was then evaporated to dryness, the remaining solid triturated with water and under stirring the pH was adjusted to about 8-9. The crude product was isolated through extraction with ethyl acetate and purified by chromatography on silica gel (eluent: dichloromethane/ethanol 1:1).

출처