반응 #155319

반응 방정식

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

수율 87.6%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타followed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   기타The catalyst was removed by celite filtration
3. 3
   기타condensed under reduced pressure
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   농축concentrated to dryness under reduced pressure

실험 절차

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

출처