반응 #155315

반응 방정식

5-bromo-6-propoxyindan

benzophenone imine

9,9-dimethyl-4,5-bis (diphenylphosphino)xanthene

cesium carbonate

ammonium chloride

→

6-propoxy-indan-5-ylamine

수율 17.0%

용매

Water

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   추출followed by extraction
3. 3
   건조The organic layer was dried over anhydrous magnesium sulfate
4. 4
   농축concentrated to dryness under reduced pressure
5. 5
   workup.DISSOLUTIONThe generated residue was dissolved in diethyl ether (130 ml)
6. 6
   workup.ADDITIONConcentrated hydrochloric acid (25 ml) was added to the solution
7. 7
   workup.STIRRINGby stirring for 2 hours
8. 8
   workup.ADDITIONA 5N aqueous sodium hydroxide solution (72 ml) was added to the reaction mixture
9. 9
   농축followed by concentration under reduced pressure
10. 10
    workup.DISSOLUTIONThe residue was dissolved in dichloromethane
11. 11
    세척washed with an aqueous saturated sodium chloride solution
12. 12
    농축The thus-obtained organic layer was concentrated to dryness under reduced pressure
13. 13
    기타the generated residue was then purified
14. 14
    농축The purified product was concentrated to dryness under reduced pressure

실험 절차

To a 5-bromo-6-propoxyindan (8.24 g, 32.2 mmol) toluene solution (80 ml) were added a benzophenone imine (6.40 g, 35.3 mmol) toluene solution (40 ml), tris(dibenzylideneacetone)dipalladium (742 mg, 0.8 mmol), 9,9-dimethyl-4,5-bis (diphenylphosphino)xanthene (XANTPHOS, 936 mg, 1.6 mmol), and cesium carbonate (15.72 g, 48.3 mmol). The resulting mixture was stirred at 100° C. under a nitrogen atmosphere for 47 hours, and then cooled to room temperature. Water and saturated ammonium chloride solution were added to the reaction mixture, followed by extraction using ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure. The generated residue was dissolved in diethyl ether (130 ml). Concentrated hydrochloric acid (25 ml) was added to the solution, followed by stirring for 2 hours. A 5N aqueous sodium hydroxide solution (72 ml) was added to the reaction mixture to adjust its pH to 11, followed by concentration under reduced pressure. The residue was dissolved in dichloromethane and washed with an aqueous saturated sodium chloride solution. The thus-obtained organic layer was concentrated to dryness under reduced pressure, and the generated residue was then purified using silica gel column chromatography (dichloromethane:ethyl acetate=90:1). The purified product was concentrated to dryness under reduced pressure, giving a pale brown oily substance of 6-propoxy-indan-5-ylamine (1.02 g, yield: 17%).

출처