반응 #155310

반응 방정식

N-(3-Propoxynaphthalen-2-yl)acetamide

hydrochloric acid

sodium hydroxide

→

3-propoxynaphthalen-2-ylamine

수율 100.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도while heating
2. 2
   온도under reflux
3. 3
   추출followed by extraction
4. 4
   농축The thus-obtained organic layer was concentrated to dryness under reduced pressure
5. 5
   기타the residue was then purified
6. 6
   농축The purified product was concentrated to dryness under reduced pressure

실험 절차

N-(3-Propoxynaphthalen-2-yl)acetamide (2.5 g, 10.2 mmol) was dissolved in ethanol (10 ml). Concentrated hydrochloric acid (5.2 ml) was added thereto, and the resulting mixture was stirred for 4 hours while heating under reflux. The reaction mixture was cooled to room temperature, and a 5N aqueous sodium hydroxide solution (12.5 ml) was added thereto to adjust its pH to 11, followed by extraction using dichloromethane. The thus-obtained organic layer was concentrated to dryness under reduced pressure, and the residue was then purified using silica gel column chromatography (dichloromethane). The purified product was concentrated to dryness under reduced pressure, giving a white powder of 3-propoxynaphthalen-2-ylamine (2.05 g, yield: 100%).

출처