반응 #1552093

반응 방정식

sodium carbonate

2-(3,3-dimethylbutyl)cyclopentanone

hydroxylamine hydrochloride

→

2-(3,3-dimethylbutyl)-N-hydroxycyclopentanimine

용매

methanol

반응 조건

후처리

1. 1
   온도the mixture is cooled to room temperature
2. 2
   여과filtered off
3. 3
   농축the product is concentrated under reduced pressure
4. 4
   추출The residue is extracted with water/diethyl ether
5. 5
   건조phase is dried with sodium sulphate
6. 6
   농축concentrated under reduced pressure

실험 절차

At 0° C., aq. sodium carbonate solution is added to a solution consisting of 20.0 g of (119 mmol) of 2-(3,3-dimethylbutyl)cyclopentanone and 16.5 g (238 mmol) of hydroxylamine hydrochloride in 200 ml of methanol until the pH is 8. The mixture is then stirred at 50° C. for 15 hours. After the reaction has ended, the mixture is cooled to room temperature and filtered off and the product is concentrated under reduced pressure. The residue is extracted with water/diethyl ether. The org. phase is dried with sodium sulphate and concentrated under reduced pressure. This gives 20.0 g (92% of theory) of an 2-(3,3-dimethylbutyl)-N-hydroxycyclopentanimine.

출처