반응 #1552087

반응 방정식

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

thionyl chloride

→

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride

반응 조건

후처리

1. 1
   온도After cooling down
2. 2
   기타the reaction mixture is evaporated under vacuum

실험 절차

3.2 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and 44.3 ml of thionyl chloride are refluxed for 5 hours. After cooling down, the reaction mixture is evaporated under vacuum to yield 3.5 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride as a yellow oil. 1H NMR (400 MHz, CHCl3-d6) δ ppm: 3.97 (s, 3H); 7.00 (t, J=52.01 Hz, 1H); IR (TQ): 1759 and 1725 cm−1 (C═O).

출처