반응 #1552084

반응 방정식

methyl 4-(4-butylphenyl)benzoate

NaOH

→

4-(4-butylphenyl)benzoic acid

수율 71.1%

용매

THF H2O

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux overnight
3. 3
   기타THF was removed
4. 4
   여과The resulting mixture was filtered
5. 5
   세척the cake was washed with water
6. 6
   기타dried

실험 절차

A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol), NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) was heated to reflux overnight. After TLC showed the reaction was complete, THF was removed. The residue was adjusted pH ˜3-4 with 2 N HCl solution. The resulting mixture was filtered and the cake was washed with water, dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%), as a white solid. (ESI) m/z 255.0 (M+H)+.

출처