반응 #1552074

반응 방정식

NaOH

Crotonaldehyde

BF3.OEt2

5-methyl-3-methylenehex-1-ene

→

3b

수율 94.0%

4-Isobutyl-6-methylcyclohex-3-enecarbaldehyde

수율 94.0%

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   온도to warm to −20° C
2. 2
   workup.STIRRINGThe solution was stirred at this temperature for a further 1.5 h
3. 3
   기타After brief agitation the phases were separated
4. 4
   세척the lower organic phase washed with water (100 ml) and brine (2×100 ml)
5. 5
   추출The combined aqueous phases were extracted with MTBE (150 ml), phase
6. 6
   기타separated
7. 7
   세척the upper organic part washed to neutral with brine
8. 8
   건조dried (Na2SO4)
9. 9
   농축concentrated in vacuo

실험 절차

Crotonaldehyde cis/trans (16 g, 230 mmol) was dissolved in methylene chloride and cooled to −30° C. With stirring, and under nitrogen, BF3.OEt2 (3.6 ml, 29 mmol) was added gradually. A solution of 5-methyl-3-methylenehex-1-ene 2 (21 g, 191 mmol) in methylene chloride (50 ml) was then added at −30° C. over 1 h and the pot allowed to warm to −20° C. The solution was stirred at this temperature for a further 1.5 h before being poured onto 2M NaOH (100 ml). After brief agitation the phases were separated and the lower organic phase washed with water (100 ml) and brine (2×100 ml). The combined aqueous phases were extracted with MTBE (150 ml), phase separated and the upper organic part washed to neutral with brine. The organic phases were combined, dried (Na2SO4) and concentrated in vacuo to afford 3b as a pale yellow oil (33 g, 94% yield; 98% pure). The product was used in the next steps without further purification.

출처